6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE

Name	TIE-2/VEGFR-2 kinase-IN-1
Synonyms	Kinase IN-1 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE 6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine
CAS	453590-24-4

Molecular Formula	C13H11N3O2
Molar Mass	241.25
Storage Condition	-20°C，密封，干燥
In vitro study	Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor.Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.

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6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE Request for Quotation